Leshinskaya, A., & Caramazza, A. (2014).
Nonmotor Aspects of Action Concepts.
Journal of Cognitive Neuroscience ,
26 (12), 2863-2879.
AbstractReading an action verb elicits the retrieval of its associated body movements as well as its typical goal—the outcome to which it is directed. Two fMRI experiments are reported in which retrieval of goal attributes was isolated from retrieval of motoric ones by contrasting actions that are either done intentionally (e.g., drink) and thus have associated goal information or by accident (e.g., hiccup). Orthogonally, the actions also varied in their motoricity (e.g., drink vs. imagine). Across both levels of motoricity, goal-directedness influenced the activity of a portion of left posterior inferior parietal lobe (pIPL). These effects were not explicable by the grammatical properties, imageability, or amount of body movement associated with these different types of verbs. In contrast, motoricity (across levels of goal-directedness) activated primarily the left middle temporal gyrus. Furthermore, pIPL was found to be distinct from the portion of left parietal lobe implicated in theory of mind, as localized in the same participants. This is consistent with the observation that pIPL contains many functionally distinct subregions and that some of these support conceptual knowledge. The present findings illustrate that, in particular, the pIPL is involved in representing attributes of intentional actions, likely their typical goals, but not their associated body movements. This result serves to describe an attribute-selective semantic subsystem for at least one type of nonmotor aspect of action knowledge.
Lingnau, A., & Caramazza, A. (2014).
The origin and function of mirror neurons: The missing link.
Behavioral and Brain Sciences ,
37 (2), 209-210.
AbstractWe argue, by analogy to the neural organization of the object recognition system, that demonstration of modulation of mirror neurons by associative learning does not imply absence of genetic adaptation. Innate connectivity defines the types of processes mirror neurons can participate in while allowing for extensive local plasticity. However, the proper function of these neurons remains to be worked out.
Fabbri, S., Strnad, L., Caramazza, A., & Lingnau, A. (2014).
Overlapping representations for grip type and reach direction.
NeuroImage ,
94, 138-146.
AbstractTo grasp an object, we need to move the arm toward it and assume the appropriate hand configuration. While previous studies suggested dorsomedial and dorsolateral pathways in the brain specialized respectively for the transport and grip components, more recent studies cast doubt on such a clear-cut distinction. It is unclear, however, to which degree neuronal populations selective for the two components overlap, and if so, to which degree they interact. Here, we used multivoxel pattern analysis (MVPA) of functional magnetic resonance imaging (fMRI) data to investigate the representation of three center-out movements (touch, pincer grip, whole-hand grip) performed in five reach directions. We found selectivity exclusively for reach direction in posterior and rostral superior parietal lobes (SPLp, SPLr), supplementary motor area (SMA), and the superior portion of dorsal premotor cortex (PMDs). Instead, we found selectivity for both grip type and reach direction in the inferior portion of dorsal premotor cortex (PMDi), ventral premotor cortex (PMv), anterior intraparietal sulcus (aIPS), primary motor (M1), somatosensory (S1) cortices and the anterior superior parietal lobe (SPLa). Within these regions, PMv, M1, aIPS and SPLa showed weak interactions between the transport and grip components. Our results suggest that human PMDi and S1 contain both grip- and reach-direction selective neuronal populations that retain their functional independence, whereas this information might be combined at the level of PMv, M1, aIPS, and SPLa.
Caramazza, A., & Egidi, G. (2014).
Mood-dependent integration in discourse comprehension: Happy and sad moods affect consistency processing via different brain networks.
NeuroImage ,
103, 20-32.
AbstractAccording to recent research on language comprehension, the semantic features of a text are not the only determinants of whether incoming information is understood as consistent. Listeners' pre-existing affective states play a crucial role as well. The current fMRI experiment examines the effects of happy and sad moods during comprehension of consistent and inconsistent story endings, focusing on brain regions previously linked to two integration processes: inconsistency detection, evident in stronger responses to inconsistent endings, and fluent processing (accumulation), evident in stronger responses to consistent endings. The analysis evaluated whether differences in the BOLD response for consistent and inconsistent story endings correlated with self-reported mood scores after a mood induction procedure. Mood strongly affected regions previously associated with inconsistency detection. Happy mood increased sensitivity to inconsistency in regions specific for inconsistency detection (e.g., left IFG, left STS), whereas sad mood increased sensitivity to inconsistency in regions less specific for language processing (e.g., right med FG, right SFG). Mood affected more weakly regions involved in accumulation of information. These results show that mood can influence activity in areas mediating well-defined language processes, and highlight that integration is the result of context-dependent mechanisms. The finding that language comprehension can involve different networks depending on people's mood highlights the brain's ability to reorganize its functions.